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首頁-技術(shù)文章-H-Cube 連續(xù)流動(dòng)氫化儀在保護(hù)基脫除方面的應(yīng)用

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H-Cube 連續(xù)流動(dòng)氫化儀在保護(hù)基脫除方面的應(yīng)用

更新時(shí)間：2012-06-25       點(diǎn)擊次數(shù)：2808

INTRODUCTION
        Protecting groups play a central role in modern organic synthesis. The benzyl groups and benzyl carbamate or Cbz groups are some of the most commonly used protecting groups and play a central role in the protection of alcohols, carboxylic acids, and amines. The benzyl and
benzyl carbamate groups are removed using catalytic hydrogenation using elevated temperature. The H-Cube®is able to remove benzyl groups from amines, acids, or alcohols very effi ciently in one pass through a 10% Pd/C CatCart®. This application note gives examples of deprotection reactions performed on the H-Cube® from the recent articles.

 


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